The Fountain Park Project

The Fountain Park Project

Menu

How to solve problems 🦢Solving Aging

Fiction 📓The Hike

Other Projects Arcadia DEEPWAVE

You can comment on everything. Or give me (harsh) personal feedback.

Made with 💙 by me (how to).

Dedicated to my family.

image
Status: Draft, early Project Outline Epistemic status: Extremely weak This is a early version of how a Coordinated Research Project for solving aging could look like, given my current assumptions.

We are complex multicellular organisms that have grown from two single cells to a trillion. This growth and the upkeep of the adult organism requires significant collaboration between cells and collective decision-making by cellular communities. We believe that the primary "master" driver of aging is the degeneration of this intercellular communication. Whether this is caused by bottom-up damage causing loss of signal transmission and reception or top-down forgetting or destruction of the morphological goal state does not matter: we predict simple restoration of intercellular communication patterns will lead to robust lifespan increases.

In order to test this hypothesis we are launching a new coordinated research effort, a collection of programs, institutions, FROs prizes and tools to read, write and understand the signals between cells. The following is a list of technologies needed to fully understand intercellular communication on all scales

Cells

Maybe not even needed, assumes we have to understand things before we can intevene.

Goal: Deterministic Control of Cell Futures

Input: Cells-on-a-Chip

Output: Cell State Identifier

Simulation: Multi-input BETSIE

Organs

Goal: 3D Video from Embryo to Death

Input: Ex Vivo Organ Models

How can we modulate in-vivo

Output: Multi-cell in-vivo Patch Clamp Array

How can we see what’s going on within tissues? How do animals and organisms grow, and which signals determine homeostasis of the morphological state?

Simulation: Electrome Clocks

Organism

Goal: Full Body Developmental Control

Input: Animal Models with Real Aging

Output: Continuous Exosome Monitor

Simulation: Exosome Clocks